Adenosine Receptor Agonist

Adenosine Receptor Agonists (55):

Cat. No.	Product Name	Effect	Purity

HY-103173

5'-N-Ethylcarboxamidoadenosine	Agonist	99.86%
5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist.

HY-N0092

Inosine	Agonist	99.61%
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors.

HY-13201A

CGS 21680 Hydrochloride	Agonist	99.70%
CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a K_i of 27 nM.

HY-103171

BAY 60-6583	Agonist	99.97%
BAY 60-6583 is a potent and high-affinity agonist of adenosine A_2B receptor (EC₅₀ = 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with K_i values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model.

HY-12365

Namodenoson	Agonist	99.75%
Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (K_i=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.

HY-A0168

Regadenoson	Agonist	99.59%
Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS.

HY-13591

Piclidenoson	Agonist	99.28%
Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19.

HY-A0181A

Adenosine 5'-monophosphate monohydrate	Agonist	99.07%
Adenosine 5'-monophosphate monohydrate is an adenosine A₁ receptor agonist. Adenosine 5'-monophosphate monohydrate has significant antiviral activity against HSV-1 and HSV-2.

HY-103181

N6-Cyclopentyladenosine	Agonist	99.59%
N6-Cyclopentyladenosine (CPA) is a selective Adenosine A₁ receptor agonist, with K_i values of 2.3 nM, 790 nM and 43 nM for human A₁, A_2A and A₃ receptors, respectively.

HY-14917

Capadenoson	Agonist	99.62%
Capadenoson is a selective agonist of adenosine-A1 receptor.

HY-18939

N6-Cyclohexyladenosine	Agonist	99.98%
N6-Cyclohexyladenosine is a selective adenosine A1 receptor agonist (EC50 = 8.2 nM).

HY-18978

GR79236	Agonist	99.79%
GR79236 is a highly potent, selective and orally active adenosine A1 receptor agonist with a K_is of 3.1 nM and 1300 nM for A1 and A2 receptors, respectively. GR79236 has anti-nociceptive and anti-inflammatory actions.

HY-139644

MIPS521	Agonist	99.65%
MIPS521 is a positive allosteric modulator of adenosine A₁ receptor (A₁AR). MIPS521 also has a lower A₁R allosteric affinity (pK_B=4.95; K_B=11 μM). MIPS521 exhibits pain-relieving effects in vivo through modulation of the increased levels of endogenous adenosine.

HY-18776

A2AR-agonist-1	Agonist	99.05%
A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.

HY-111809

N6-Ethyladenosine	Agonist	99.53%
N6-Ethyladenosine is an adenosine derivative, acts as a Adenosine receptor agonist, with K_is of 4.9 and 4.7 nM for hA₁AR and hA₃AR, respectively.

HY-19365

AB-MECA	Agonist	98.01%
AB-MECA is a high affinity A₃ adenosine receptor agonist with a binding K_i of 430.5 nM for human A₃ receptors in CHO cells. AB-MECA can enhance plasma histamine level.

HY-101854

N6-(2-Phenylethyl)adenosine	Agonist	99.41%
N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine), an adenosine derivative, is a potent adenosine receptors (AR) agonist with K_i values of 11.8 nM, 30.1 nM, 0.63 nM for rat A₁AR, human A₁AR and hA₃AR, respectively.

HY-103180

2-Chloro-N-cyclopentyl-2′-C-methyladenosine	Agonist	99.79%
2'-MeCCPA is a potent and selective A1 adenosine receptors (A1AR) agonist. 2'-MeCCPA efficiently inhibits cAMP modulation in both direct pathway medium spiny neurons (dMSNs) and indirect pathway medium spiny neurons (iMSNs).

HY-18687

APNEA	Agonist	98.96%
APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent, non-selective A3 adenosine receptor agonist.

HY-106007

Trabodenoson	Agonist	99.97%
Trabodenoson (INO-8875), an adenosine mimetic, is a highly selective Adenosine A1 receptor agonist. Trabodenoson (INO-8875) is used in the study for Primary Open-Angle Glaucoma.

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